Applied Rheological Research on Ointment Bases [antikvár]

The correlations between rheological characteristics and composition were investigated by means of tests carried out with 26 series of nonaqueous and emulsified ointment bases. Rheological similarities were established on the basis of the flow curves. Differences m the structural forces were characterized by means of the concentration functions and the criteria of optimum compositions are discussed. Introduction Ointment bases are built in a complex way to give a coherent structure often composed of 6 to 10 ingredients. Decades ago, rheology proved to furnish suitable methods for the characterization of ointments and for discussing the quantitative relation- ships of the forces acting within the coherent systems. Rheological data made possible an accurate definition of various ointments, together with the precise delineation of quality requirements. A number of attempts are known [1—7] aiming at the utilization of rheological information in the devising of adequate compositions and technologies of production. Despite the many-sided studies and great amount of experimental data, no consensus of opinion has been reached in connection with the following ques- tions : — which are the rheological parameters that best characterize the struc- ture of an ointment, giving the most information on the forces that keep the coherent gel skeleton together ? — which are the rheological parameters that have a direct bearing upon the use of ointments in therapeutic practice ? — what are the correspondences between data obtained by various methods ? — which are the methods of rheological testing suitable for intra- production and final quality control? — are rheological norms necessary ? * This research was supported by the Ministry of Health, Hungary (02-4-18/458). ** To whom correspondence should be addressed. Acta Chim. Hung. 115, 1984